Beta-Caryophyllene - Terpene Profile
Characterized by its spicy and peppery odor.
Characterized by its spicy and peppery odor. This sesquiterpene is most commonly found in cloves, black pepper, basil, oregano and cannabis. There are 3 isomers (α-, β-, and γ-caryophyllene) in nature, however β-Caryophyllene is the most frequently encountered and most abundant of the isomers. In addition, as an outstanding feature, β-Caryophyllene is suggested to bind with CB2 receptors and activate the endocannabinoid system. β-Caryophyllene dose not produce a psychoactive effect.
Found in:
Black Pepper
Medicinal qualities:
In Vivo / Anti-inflammatory
β-Caryophyllene, the major constituent of copaiba oil, reduces systemic inflammation and oxidative stress in arthritic rats
Ames-Sibin, A. P., Barizão, C. L., Castro-Ghizoni, C. V., Silva, F. M. S., Sá-Nakanishi, A. B., Bracht, L., Bersani-Amado, C. A., & Marçal-Natali, M. R. (2018)
In Vivo / Anti-inflammatory
β-Caryophyllene, the major constituent of copaiba oil, reduces systemic inflammation and oxidative stress in arthritic rats
Ames-Sibin, A. P., Barizão, C. L., Castro-Ghizoni, C. V., Silva, F. M. S., Sá-Nakanishi, A. B., Bracht, L., Bersani-Amado, C. A., & Marçal-Natali, M. R. (2018)
In Vitro / Skin Repair
Synergistic interaction of β-caryophyllene with aromadendrene oxide 2 and phytol induces apoptosis on skin epidermoid cancer cells
Pavithra PS, Mehta A, Verma RS. (2018)
In Vitro / Skin Repair
Synergistic interaction of β-caryophyllene with aromadendrene oxide 2 and phytol induces apoptosis on skin epidermoid cancer cells
Pavithra PS, Mehta A, Verma RS. (2018)
In Vivo / Anti-inflammatory
Anti-Inflammatory, Antioxidant, Antibiotic, and Cytotoxic Activities of Tanacetum vulgare L. Essential Oil and Its Constituents
Héloïse Coté, Marie-Anne Boucher, André Pichette, and Jean Legault (2017)
In Vivo / Anti-inflammatory
Anti-Inflammatory, Antioxidant, Antibiotic, and Cytotoxic Activities of Tanacetum vulgare L. Essential Oil and Its Constituents
Héloïse Coté, Marie-Anne Boucher, André Pichette, and Jean Legault (2017)
In Vivo / Anti-Cancer
β-caryophyllene and β-caryophyllene oxide-natural compounds of anticancer and analgesic properties
Fidyt K, Fiedorowicz A, Strządała L, Szumny A. (2016)
In Vivo / Anti-Cancer
β-caryophyllene and β-caryophyllene oxide-natural compounds of anticancer and analgesic properties
Fidyt K, Fiedorowicz A, Strządała L, Szumny A. (2016)
In Vivo / Increase Longevity And Mitochondrial Function
β-caryophyllene, a dietary cannabinoid, complexed with β-cyclodextrin produced anti-hyperalgesic effect involving the inhibition of Fos expression in superficial dorsal horn
Quintans-Júnior LJ1, Araújo AA, Brito RG, Santos PL, Quintans JS, Menezes PP2, Serafini MR, Silva GF, Carvalho FM, Brogden NK, Sluka KA. (2016)
In Vivo / Increase Longevity And Mitochondrial Function
β-caryophyllene, a dietary cannabinoid, complexed with β-cyclodextrin produced anti-hyperalgesic effect involving the inhibition of Fos expression in superficial dorsal horn
Quintans-Júnior LJ1, Araújo AA, Brito RG, Santos PL, Quintans JS, Menezes PP2, Serafini MR, Silva GF, Carvalho FM, Brogden NK, Sluka KA. (2016)
In Vitro / Skin Absorption
Determination of β-caryophyllene skin permeation/retention from crude copaiba oil (Copaifera multijuga Hayne) and respective oil-based nanoemulsion using a novel HS-GC/MS method
Lucca LG, de Matos SP, Borille BT, de O Dias D, Teixeira HF, Veiga VF Jr, Limberger RP, Koester LS. (2015)
In Vitro / Skin Absorption
Determination of β-caryophyllene skin permeation/retention from crude copaiba oil (Copaifera multijuga Hayne) and respective oil-based nanoemulsion using a novel HS-GC/MS method
Lucca LG, de Matos SP, Borille BT, de O Dias D, Teixeira HF, Veiga VF Jr, Limberger RP, Koester LS. (2015)
In Vivo / Anti-anxiety
β-Caryophyllene, a CB2 receptor agonist produces multiple behavioral changes relevant to anxiety and depression in mice
Bahi, A., Al Mansouri, S., Al Memari, E., Al Ameri, M., Nurulain, S. M., & Ojha, S. (2014)
In Vivo / Anti-anxiety
β-Caryophyllene, a CB2 receptor agonist produces multiple behavioral changes relevant to anxiety and depression in mice
Bahi, A., Al Mansouri, S., Al Memari, E., Al Ameri, M., Nurulain, S. M., & Ojha, S. (2014)
In Vivo / Anti-anxiety
β-Caryophyllene, a CB2 receptor agonist produces multiple behavioral changes relevant to anxiety and depression in mice
Bahi A1, Al Mansouri S, Al Memari E, Al Ameri M, Nurulain SM, Ojha S. (2014)
In Vivo / Anti-anxiety
β-Caryophyllene, a CB2 receptor agonist produces multiple behavioral changes relevant to anxiety and depression in mice
Bahi A1, Al Mansouri S, Al Memari E, Al Ameri M, Nurulain SM, Ojha S. (2014)
In Vivo / Anti-Cancer
Beta caryophyllene and caryophyllene oxide, isolated from Aegle marmelos, as the potent anti-inflammatory agents against lymphoma and neuroblastoma cells
Sain S, Naoghare PK, Devi SS, Daiwile A, Krishnamurthi K, Arrigo P, Chakrabarti T (2014)
In Vivo / Anti-Cancer
Beta caryophyllene and caryophyllene oxide, isolated from Aegle marmelos, as the potent anti-inflammatory agents against lymphoma and neuroblastoma cells
Sain S, Naoghare PK, Devi SS, Daiwile A, Krishnamurthi K, Arrigo P, Chakrabarti T (2014)
In Vivo / Prevent Diabetes
β-Caryophyllene, a natural sesquiterpene, modulates carbohydrate metabolism in streptozotocin-induced diabetic rats
Basha RH, Sankaranarayanan C. (2014)
In Vivo / Prevent Diabetes
β-Caryophyllene, a natural sesquiterpene, modulates carbohydrate metabolism in streptozotocin-induced diabetic rats
Basha RH, Sankaranarayanan C. (2014)
In Vivo / Antinociception
Involvement of peripheral cannabinoid and opioid receptors in β-caryophyllene-induced antinociception
Katsuyama, S., Mizoguchi, H., Kuwahata, H., Komatsu, T., Nagaoka, K., Nakamura, H., Bagetta, G., Sakurada, T., & Sakurada, S. (2013)
In Vivo / Antinociception
Involvement of peripheral cannabinoid and opioid receptors in β-caryophyllene-induced antinociception
Katsuyama, S., Mizoguchi, H., Kuwahata, H., Komatsu, T., Nagaoka, K., Nakamura, H., Bagetta, G., Sakurada, T., & Sakurada, S. (2013)
In Vivo / Increase Longevity And Mitochondrial Function
Activation of type 2 cannabinoid receptors (CB2R) promotes fatty acid oxidation through the SIRT1/PGC-1α pathway
Zheng X, Sun T, Wang X. (2013)
In Vivo / Increase Longevity And Mitochondrial Function
Activation of type 2 cannabinoid receptors (CB2R) promotes fatty acid oxidation through the SIRT1/PGC-1α pathway
Zheng X, Sun T, Wang X. (2013)
In Vivo / Relieves Pain
Involvement of peripheral cannabinoid and opioid receptors in β-caryophyllene-induced antinociception
Katsuyama S, Mizoguchi H, Kuwahata H, Komatsu T, Nagaoka K, Nakamura H, Bagetta G, Sakurada T, Sakurada S. (2013)
In Vivo / Relieves Pain
Involvement of peripheral cannabinoid and opioid receptors in β-caryophyllene-induced antinociception
Katsuyama S, Mizoguchi H, Kuwahata H, Komatsu T, Nagaoka K, Nakamura H, Bagetta G, Sakurada T, Sakurada S. (2013)
In Vivo / Anti-anxiety
The anxiolytic-like effect of an essential oil derived from Spiranthera odoratissima A. St. Hil. leaves and its major component, β-caryophyllene, in male mice
Galdino, P. M., Nascimento, M. V., Florentino, I. F., Lino, R. C., Fajemiroye, J. O., Chaibub, B. A., de Paula, J. R., de Lima, T. C., & Costa, E. A. (2012)
In Vivo / Anti-anxiety
The anxiolytic-like effect of an essential oil derived from Spiranthera odoratissima A. St. Hil. leaves and its major component, β-caryophyllene, in male mice
Galdino, P. M., Nascimento, M. V., Florentino, I. F., Lino, R. C., Fajemiroye, J. O., Chaibub, B. A., de Paula, J. R., de Lima, T. C., & Costa, E. A. (2012)
In Vivo / Anti-Cancer
β-Caryophyllene, a Compound Isolated from the Biblical Balm of Gilead (Commiphora gileadensis), Is a Selective Apoptosis Inducer for Tumor Cell Lines
Amiel E1, Ofir R, Dudai N, Soloway E, Rabinsky T, Rachmilevitch S. (2012)
In Vivo / Anti-Cancer
β-Caryophyllene, a Compound Isolated from the Biblical Balm of Gilead (Commiphora gileadensis), Is a Selective Apoptosis Inducer for Tumor Cell Lines
Amiel E1, Ofir R, Dudai N, Soloway E, Rabinsky T, Rachmilevitch S. (2012)
In Vivo / Protects Kidney
β-Caryophyllene ameliorates cisplatin-induced nephrotoxicity in a cannabinoid 2 receptor-dependent manner
Horváth B1, Mukhopadhyay P, Kechrid M, Patel V, Tanchian G, Wink DA, Gertsch J, Pacher P. (2012)
In Vivo / Protects Kidney
β-Caryophyllene ameliorates cisplatin-induced nephrotoxicity in a cannabinoid 2 receptor-dependent manner
Horváth B1, Mukhopadhyay P, Kechrid M, Patel V, Tanchian G, Wink DA, Gertsch J, Pacher P. (2012)
In Vivo / Anti-Cancer
Antimicrobial activity of terpenoids from Copaifera langsdorffii Desf. against cariogenic bacteria
Souza AB, Martins CH, Souza MG, Furtado NA, Heleno VC, de Sousa JP, Rocha EM, Bastos JK, Cunha WR, Veneziani RC, Ambrósio SR. (2011)
In Vivo / Anti-Cancer
Antimicrobial activity of terpenoids from Copaifera langsdorffii Desf. against cariogenic bacteria
Souza AB, Martins CH, Souza MG, Furtado NA, Heleno VC, de Sousa JP, Rocha EM, Bastos JK, Cunha WR, Veneziani RC, Ambrósio SR. (2011)
In Vitro / Antispasmodic - Ileum
Antispasmodic effects of essential oil of Pterodon polygalaeflorus and its main constituent β-caryophyllene on rat isolated ileum
Leonhardt, V., Leal-Cardoso, J. H., Lahlou, S., Albuquerque, A. A., Porto, R. S., Celedônio, N. R., Oliveira, A. C., Pereira, R. F., Silva, L. P., Garcia-Teófilo, T. M., Silva, A. P., Magalhães, P. J., Duarte, G. P., & Coelho-de-Souza, A. N. (2010)
In Vitro / Antispasmodic - Ileum
Antispasmodic effects of essential oil of Pterodon polygalaeflorus and its main constituent β-caryophyllene on rat isolated ileum
Leonhardt, V., Leal-Cardoso, J. H., Lahlou, S., Albuquerque, A. A., Porto, R. S., Celedônio, N. R., Oliveira, A. C., Pereira, R. F., Silva, L. P., Garcia-Teófilo, T. M., Silva, A. P., Magalhães, P. J., Duarte, G. P., & Coelho-de-Souza, A. N. (2010)
In Vivo / Anti-inflammatory
Investigation of the anti-inflammatory and analgesic activities of β-Caryophyllene
Bakır, B., Him, A., Özbek, H., Düz, E., & Tütüncü, M. (2008)
In Vivo / Anti-inflammatory
Investigation of the anti-inflammatory and analgesic activities of β-Caryophyllene
Bakır, B., Him, A., Özbek, H., Düz, E., & Tütüncü, M. (2008)
In Vivo / Prevent Alzheimer's Disease
PPARgamma agonists as therapeutics for the treatment of Alzheimer's disease
Landreth G1, Jiang Q, Mandrekar S, Heneka M. (2008)
In Vivo / Prevent Alzheimer's Disease
PPARgamma agonists as therapeutics for the treatment of Alzheimer's disease
Landreth G1, Jiang Q, Mandrekar S, Heneka M. (2008)
In Vivo / Anti-Cancer
Potentiating effect of beta-caryophyllene on anticancer activity of alpha-humulene, isocaryophyllene and paclitaxel
Legault J1, Pichette A. (2007)
In Vivo / Anti-Cancer
Potentiating effect of beta-caryophyllene on anticancer activity of alpha-humulene, isocaryophyllene and paclitaxel
Legault J1, Pichette A. (2007)
In Vivo / Anti-inflammatory
Anti-inflammatory effects of compounds alpha-humulene and (-)-trans-caryophyllene isolated from the essential oil of Cordia verbenacea
Fernandes, E. S., Passos, G. F., Medeiros, R., da Cunha, F. M., Ferreira, J., Campos, M. M., Pianowski, L. F., & Calixto, J. B. (2007)
In Vivo / Anti-inflammatory
Anti-inflammatory effects of compounds alpha-humulene and (-)-trans-caryophyllene isolated from the essential oil of Cordia verbenacea
Fernandes, E. S., Passos, G. F., Medeiros, R., da Cunha, F. M., Ferreira, J., Campos, M. M., Pianowski, L. F., & Calixto, J. B. (2007)
In Vivo / Anti-inflammatory
Amelioration of dextran sulfate sodium-induced colitis in mice by oral administration of beta-caryophyllene, a sesquiterpene
Cho, J. Y., Chang, H. J., Lee, S. K., Kim, H. J., Hwang, J. K., & Chun, H. S. (2007)
In Vivo / Anti-inflammatory
Amelioration of dextran sulfate sodium-induced colitis in mice by oral administration of beta-caryophyllene, a sesquiterpene
Cho, J. Y., Chang, H. J., Lee, S. K., Kim, H. J., Hwang, J. K., & Chun, H. S. (2007)
In Vivo / Increase Longevity And Mitochondrial Function
Local anaesthetic activity of beta-caryophyllene
Ghelardini C1, Galeotti N, Di Cesare Mannelli L, Mazzanti G, Bartolini A. (2001)
In Vivo / Increase Longevity And Mitochondrial Function
Local anaesthetic activity of beta-caryophyllene
Ghelardini C1, Galeotti N, Di Cesare Mannelli L, Mazzanti G, Bartolini A. (2001)
State of Matter
Liquid
Boiling Point
130°C
High Beta-Myrcene strain-specific terpene formulations:
Pineapple Express
Bright pineapple and citrus notes blend with earthy pine for a vibrant, tropical, and refreshing aroma experience
Pineapple Express
Bright pineapple and citrus notes blend with earthy pine for a vibrant, tropical, and refreshing aroma experience
Pineapple Express
Bright pineapple and citrus notes blend with earthy pine for a vibrant, tropical, and refreshing aroma experience
Pineapple Express
Bright pineapple and citrus notes blend with earthy pine for a vibrant, tropical, and refreshing aroma experience
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